Restorative Therapies in Parkinsons Disease
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Parkinsons disease PD is a common neurodegenerative disease, characterized by a selective loss of midbrain dopaminergic DA neurons. To address this problem, various types of stem cells that have potential to differentiate into DA neurons are being investigated as cellular therapies for PD, including cells derived from embryonic or adult donor tissue, and embryonic stem cells.
Emerging restorative treatments for Parkinson's disease.
These cell sources, however. Recent progress in adult stems has further proved that the cells derived from adult tissue could be expanded and differentiated into DA precursor cells in vitro, and cell therapy with adult stem cells could produce a clear improvement for PD models. Using adult stem cells for clinic application may not only overcome the ethical problem inherent in using human fetal tissue or embryonic stem cells, but also open the possibility for autologous transplantation.
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The patient-specific adult stem cell is therefore a potential and prospective candidate for PD treatment. Keywords: Parkinson's disease, dopaminergic neurons, adult stem cells, neural stem cells, induced pluripotent stem cells, embryonic stem cells, mesenchymal stem cells, carotid body stem cells, cell transplantation therapy, fetal stem cells, FOXA2.
Frontiers | Emerging Treatment Approaches for Parkinson’s Disease | Neuroscience
Abstract: Parkinsons disease PD is a common neurodegenerative disease, characterized by a selective loss of midbrain dopaminergic DA neurons. Volume 10 , Issue 4 , Use of placebo surgery in controlled trials of a cellular-based therapy for Parkinson's disease. Thomas B. Freeman , Dorothy E.
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Warren Olanow. Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research Gerard J.
Clinical neurotransplantation: Core assessment protocol rather than sham surgery as control Gerard J. Sham surgery controls: intracerebral grafting of fetal tissue for Parkinson's disease and proposed criteria for use of sham surgery controls.
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Patrick Kesslak. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Jeffrey H. Kordower , Marina E. Benefits and risks of hosting animal cells in the human brain O.
Isacson , Xandra O Breakefield. Related Papers.